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Hepatitis means inflammation of the liver, and viruses are often -- but not always -- the cause.

Other forms of the disease include drug-induced, fatty liver and auto-immune hepatitis.

There are six types of hepatitis related to viruses: A, B, C, D, E and G.

Some do not result in serious disease, and vaccines are given for A and B. But chronic hepatitis C (or "hep C" or "HCV") is the most common form and the hardest to treat. It is also what doctors are seeing more of in the Midcoast.

It can result in cirrhosis (a permanently scarred liver that prevents blood from flowing through it), liver failure and liver cancer.

Liver failure due to hepatitis C is currently the leading cause of liver transplants in this country.

Hepatitis C is a virus and can be contracted in the following ways:

* Accidental pricks from needles used on patients carrying the disease
* Getting a tattoo with dirty needles or piercing ears and the body with dirty needles
* Injecting drugs with contaminated needles
* Snorting drugs with a straw that has become contaminated
* Sharing a razor, toothbrush or other personal item used by someone with hepatitis C
* Undergoing kidney machine treatment
* Undergoing an organ transplant or blood transfusion prior to 1992
* Getting a manicure with contaminated instruments
* Acupuncture

In other words, it's fairly easy to pick up the virus, and many patients -- as many as 40 percent of the almost 5 million in the United States -- don't know how they picked up the disease. Former U.S. Surgeon General C. Everett Koop called it "an epidemic for anyone."

Once infected with hepatitis C, a person can be contagious to others in as short a time span as two weeks. Because the disease arrives virtually asymptomatic in its early stages, a blood test is the only way to detect it. Some develop problems within five years of getting the virus; others feel fine even 20 years later. In 15 percent of cases, the liver rids itself of the virus.

Until the early 1990s, there was no test for hepatitis C and patients infected with it were merely diagnosed as having a form of hepatitis different from the familiar forms.

Complicating the virus is its tendency to mutate into diverse genotypes. In the Midcoast, doctors see predominantly genotype 1a (which is also common in South America and Australia), whereas in Europe and Asia genotype 1b is more common.

There are currently approximately 4 million people in the United States afflicted with hepatitis C and 60 to 85 percent of all infections develop into chronic infections, with individuals living with the virus for years.

Treatments include doses of interferon and ribavarin, but they don't always work. Liver transplants are also becoming more common.

Anadys Pharmaceuticals Announces Publication of Clinical Study of Isatoribine in Chronic Hepatitis C Demonstrating
RedNova Tue, 23 Aug 2005 7:22 AM PDT
SAN DIEGO, Aug. 23 /PRNewswire-FirstCall/ -- Anadys Pharmaceuticals, Inc.

Gilead, Achillion initiate phase I trial evaluating GS 9132 for treatment of hep C
PharmaBiz Mon, 22 Aug 2005 7:46 PM PDT
Gilead Sciences and Achillion Pharmaceuticals have begun dosing patients in a Phase I study of GS 9132, also known as ACH-806. Gilead and Achillion are investigating GS 9132 for the treatment of hepatitis C.

Cuts keep patients waiting for drugs
Telegraph.co.uk Tue, 23 Aug 2005 5:37 AM PDT
Tens of thousands of patients face potentially fatal delays in receiving the best drugs for their diseases because of Government cuts.

Pharmasset Earns Milestone Payment for Reverset(TM) Study 203 Results
RedNova Tue, 23 Aug 2005 5:05 AM PDT
PRINCETON, N.J., Aug. 23 /PRNewswire/ -- Pharmasset announced today that the company earned a milestone payment from Incyte Corporation as a result of Reverset exceeding the contractually-defined goal of a 1.0 log10 reduction in HIV viral load in Study 203.

BRIEFING - ASIA HEALTH - AUG 23, 2005
Asia Pulse via Yahoo! Australia & NZ Finance Tue, 23 Aug 2005 1:16 AM PDT
Health / Pharmaceuticals Hyderabad-based Dr Reddy's Laboratories has received tentative approval from the United States Food and Drug Administration (USFDA) for diabetes drug Glimepiride.

Briefing - Asia Health - Aug 23, 2005
Asia Pulse via Yahoo! Asia News Tue, 23 Aug 2005 0:52 AM PDT
An executive briefing on Health for Aug 23, 2005, prepared by Asia Pulse (http://www.asiapulse.com), the real-time, Asia-based wire with exclusive news, commercial intelligence and business opportunities. INDIA'S DR REDDY'S GETS TENTATIVE USFDA NOD FOR DIABETIC DRUG

Nabi Biopharmaceuticals Appoints Leslie Hudson, Ph.D., To Its Board of Directors
RedNova Mon, 22 Aug 2005 4:26 PM PDT
BOCA RATON, Fla., Aug. 22 /PRNewswire-FirstCall/ -- Nabi Biopharmaceuticals announced today that it has elected Leslie Hudson, Ph.D., to its board of directors. Dr.

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